Proposed Therapeutic Range of Treosulfan in Reduced Toxicity Pediatric Allogeneic Hematopoietic Stem Cell Transplant Conditioning: Results From a Prospective Trial

Treosulfan is given off‐label in pediatric allogeneic hematopoietic stem cell transplant. This study investigated treosulfan's pharmacokinetics (PKs), efficacy, and safety in a prospective trial. Pediatric patients (n = 87) receiving treosulfan‐fludarabine conditioning were followed for at leas...

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Detalhes bibliográficos
Publicado no:Clin Pharmacol Ther
Main Authors: Chiesa, Robert, Standing, Joseph F., Winter, Robert, Nademi, Zohreh, Chu, Jan, Pinner, Danielle, Kloprogge, Frank, McLellen, Susan, Amrolia, Persis J., Rao, Kanchan, Lucchini, Giovanna, Silva, Juliana, Ciocarlie, Oana, Lazareva, Arina, Gennery, Andrew R., Doncheva, Bilyana, Cant, Andrew J., Hambleton, Sophie, Flood, Terence, Rogerson, Elizabeth, Devine, Kirsty, Prunty, Helen, Heales, Simon, Veys, Paul, Slatter, Mary
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484914/
https://ncbi.nlm.nih.gov/pubmed/31701524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.1715
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