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Conjugated activation of myocardial-specific transcription of Gja5 by a pair of Nkx2-5-Shox2 co-responsive elements
The sinoatrial node (SAN) is the primary pacemaker in the heart. During cardiogenesis, Shox2 and Nkx2–5 are co-expressed in the junction domain of the SAN and regulate pacemaker cell fate through a Shox2-Nkx2–5 antagonism. Cx40 is a marker of working myocardium and an Nkx2–5 transcriptional output a...
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| Publicado en: | Dev Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7484358/ https://ncbi.nlm.nih.gov/pubmed/32687896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2020.07.003 |
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