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Improved annotation of untargeted metabolomics data through buffer modifications that shift adduct mass and intensity

Annotation of untargeted high-resolution full-scan LC-MS metabolomics data remains challenging due to individual metabolites generating multiple LC-MS peaks arising from isotopes, adducts and fragments. Adduct annotation is a particular challenge, as the same mass difference between peaks can arise...

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Detalhes bibliográficos
Publicado no:Anal Chem
Main Authors: Lu, Wenyun, Xing, Xi, Wang, Lin, Chen, Li, Zhang, Sisi, McReynolds, Melanie R., Rabinowitz, Joshua D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7484094/
https://ncbi.nlm.nih.gov/pubmed/32614575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.analchem.0c00985
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