MEK1/2 Inhibition in Murine Heart and Aorta After Oral Administration of Refametinib Supplemented Drinking Water

Upregulation of the RAS-RAF-MEK-ERK-MAPK pathway is involved in the development of several human tumors, aortic aneurysms, atherosclerosis, and cardiomyopathy. Refametinib, a highly selective MEK-inhibitor, has already shown antineoplastic activity in phase II trials. Furthermore, it showed potency...

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Vydáno v:Front Pharmacol
Hlavní autoři: Steijns, Felke, Bracke, Nathalie, Renard, Marjolijn, De Backer, Julie, Sips, Patrick, Debunne, Nathan, Wynendaele, Evelien, Verbeke, Frederick, De Spiegeleer, Bart, Campens, Laurence
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2020
Témata:
Pharmacology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483920/
https://ncbi.nlm.nih.gov/pubmed/32982746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01336
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