A Decrease in Transcription Capacity Limits Growth Rate upon Translation Inhibition

In bacterial cells, inhibition of ribosomes by sublethal concentrations of antibiotics leads to a decrease in the growth rate despite an increase in ribosome content. The limitation of ribosomal activity results in an increase in the level of expression from ribosomal promoters; this can deplete the...

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Bibliographic Details
Published in:mSystems
Main Authors: Zhang, Qing, Brambilla, Elisa, Li, Rui, Shi, Hualin, Cosentino Lagomarsino, Marco, Sclavi, Bianca
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483510/
https://ncbi.nlm.nih.gov/pubmed/32900870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSystems.00575-20
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