A small molecular compound CC1007 induces cross-lineage differentiation by inhibiting HDAC7 expression and HDAC7/MEF2C interaction in BCR-ABL1(−) pre-B-ALL

Histone deacetylase 7 (HDAC7), a member of class IIa HDACs, has been described to be an important regulator for B cell development and has a potential role in B cell acute lymphoblastic leukemia (B-ALL). CC1007, a BML-210 analog, is designed to indirectly inhibit class IIa HDACs by binding to myocyt...

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Dettagli Bibliografici
Pubblicato in:Cell Death Dis
Autori principali: Wang, Zhihua, Zhang, Yang, Zhu, Shicong, Peng, Hongling, Chen, Yongheng, Cheng, Zhao, Liu, Sufang, Luo, Yunya, Li, Ruijuan, Deng, Mingyang, Xu, Yunxiao, Hu, Guoyu, Chen, Lin, Zhang, Guangsen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483467/
https://ncbi.nlm.nih.gov/pubmed/32913188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-020-02949-1
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