CYLD exaggerates pressure overload-induced cardiomyopathy via suppressing autolysosome efflux in cardiomyocytes

Deubiquitinating enzymes (DUBs) appear to be a new class of regulators of cardiac homeostasis and disease. However, DUB-mediated signaling in the heart is not well understood. Herein we report a novel mechanism by which cylindromatosis (CYLD), a DUB mediates cardiac pathological remodeling and dysfu...

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Veröffentlicht in:J Mol Cell Cardiol
Hauptverfasser: Qi, Lei, Zang, Huimei, Wu, Weiwei, Nagarkatti, Prakash, Nagarkatti, Mitzi, Liu, Qinghang, Robbins, Jeffrey, Wang, Xuejun, Cui, Taixing
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483359/
https://ncbi.nlm.nih.gov/pubmed/32553594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2020.06.004
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