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Microglia phagocytose myelin sheaths to modify developmental myelination

During development, oligodendrocytes contact and wrap neuronal axons with myelin. Similar to neurons and synapses, excess myelin sheaths are produced and selectively eliminated, but how elimination occurs is unknown. Microglia, the resident immune cells of the CNS, engulf surplus neurons and synapse...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Hughes, Alexandria N., Appel, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7483351/
https://ncbi.nlm.nih.gov/pubmed/32632287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-020-0654-2
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