An Amyotrophic Lateral Sclerosis-Associated Mutant of C21ORF2 Is Stabilized by NEK1-Mediated Hyperphosphorylation and the Inability to Bind FBXO3

C21ORF2 and NEK1 have been identified as amyotrophic lateral sclerosis (ALS)-associated genes. Both genes are also mutated in certain ciliopathies, suggesting that they might contribute to the same signaling pathways. Here we show that FBXO3, the substrate receptor of an SCF ubiquitin ligase complex...

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Publicado no:iScience
Main Authors: Watanabe, Yasuaki, Nakagawa, Tadashi, Akiyama, Tetsuya, Nakagawa, Makiko, Suzuki, Naoki, Warita, Hitoshi, Aoki, Masashi, Nakayama, Keiko
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7481237/
https://ncbi.nlm.nih.gov/pubmed/32891887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101491
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