Widespread tissue hypoxia dysregulates cell and metabolic pathways in SMA

OBJECTIVE: The purpose of the study was to determine the extent and role of systemic hypoxia in the pathogenesis of spinal muscular atrophy (SMA). METHODS: Hypoxia was assayed in vivo in early‐symptomatic (postnatal day 5) SMA‐model mice by pimonidazole and [(18)F]‐Fluoroazomycin arabinoside injecti...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Hernandez‐Gerez, Elena, Dall’Angelo, Sergio, Collinson, Jon M., Fleming, Ian N., Parson, Simon H.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480929/
https://ncbi.nlm.nih.gov/pubmed/32790171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.51134
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