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Demyelination in hereditary sensory neuropathy type‐1C

OBJECTIVE: Sphingolipids are enriched in the nerves. Serine‐palmitoyltransferase (SPT) catalyzes the key step of sphingolipids biosynthesis. Mutations in SPT subunits (SPTLC) lead to the excessive production of neurotoxic deoxysphingolipids (DoxSLs) in patients with Hereditary Sensory Neuropathy Typ...

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Detalhes bibliográficos
Publicado no:Ann Clin Transl Neurol
Main Authors: Saba, Sadaf, Chen, Yongsheng, Maddipati, Krishna Rao, Hackett, Melody, Hu, Bo, Li, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480917/
https://ncbi.nlm.nih.gov/pubmed/32730653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/acn3.51110
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