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Epithelial organ shape is generated by patterned actomyosin contractility and maintained by the extracellular matrix

Epithelial sheets define organ architecture during development. Here, we employed an iterative multiscale computational modeling and quantitative experimental approach to decouple direct and indirect effects of actomyosin-generated forces, nuclear positioning, extracellular matrix, and cell-cell adh...

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Bibliografske podrobnosti
izdano v:PLoS Comput Biol
Main Authors: Nematbakhsh, Ali, Levis, Megan, Kumar, Nilay, Chen, Weitao, Zartman, Jeremiah J., Alber, Mark
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2020
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480841/
https://ncbi.nlm.nih.gov/pubmed/32817654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1008105
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