EZH2 regulates sFRP4 expression without affecting the methylation of sFRP4 promoter DNA in colorectal cancer cell lines

Abnormal activation of the Wnt signaling pathway is found in 90% of colorectal cancers (CRCs). Secreted frizzled-related protein 4 (sFRP4) serves as an antagonist of the canonical Wnt signaling pathway. Epigenetic alterations, including changes in DNA methylation and histone methylation, may influen...

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Udgivet i:Exp Ther Med
Main Authors: Liu, Yuting, Yu, Jun, Xie, Yang, Li, Mengying, Wang, Feng, Zhang, Jing, Qi, Jian
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2020
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7480130/
https://ncbi.nlm.nih.gov/pubmed/32952624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/etm.2020.9160
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