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Cofilin Loss in Drosophila Muscles Contributes to Muscle Weakness through Defective Sarcomerogenesis during Muscle Growth

Sarcomeres, the fundamental contractile units of muscles, are conserved structures composed of actin thin filaments and myosin thick filaments. How sarcomeres are formed and maintained is not well understood. Here, we show that knockdown of Drosophila cofilin (DmCFL), an actin depolymerizing factor,...

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Vydáno v:Cell Rep
Hlavní autoři: Balakrishnan, Mridula, Yu, Shannon F., Chin, Samantha M., Soffar, David B., Windner, Stefanie E., Goode, Bruce L., Baylies, Mary K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479987/
https://ncbi.nlm.nih.gov/pubmed/32697999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.107893
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