Chromatin modifier MTA1 regulates mitotic transition and tumorigenesis by orchestrating mitotic mRNA processing

Dysregulated alternative splicing (AS) driving carcinogenetic mitosis remains poorly understood. Here, we demonstrate that cancer metastasis-associated antigen 1 (MTA1), a well-known oncogenic chromatin modifier, broadly interacts and co-expresses with RBPs across cancers, contributing to cancerous...

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Vydáno v:Nat Commun
Hlavní autoři: Liu, Jian, Li, Chunxiao, Wang, Jinsong, Xu, Dongkui, Wang, Haijuan, Wang, Ting, Li, Lina, Li, Hui, Nan, Peng, Zhang, Jingyao, Wang, Yang, Huang, Changzhi, Chen, Dong, Zhang, Yi, Wen, Tao, Zhan, Qimin, Ma, Fei, Qian, Haili
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479136/
https://ncbi.nlm.nih.gov/pubmed/32901005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18259-1
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