Enhancing microtubule stabilization rescues cognitive deficits and ameliorates pathological phenotype in an amyloidogenic Alzheimer’s disease model

In Alzheimer’s disease (AD), and other tauopathies, microtubule destabilization compromises axonal and synaptic integrity contributing to neurodegeneration. These diseases are characterized by the intracellular accumulation of hyperphosphorylated tau leading to neurofibrillary pathology. AD brains a...

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Pubblicato in:Sci Rep
Autori principali: Fernandez-Valenzuela, Juan Jose, Sanchez-Varo, Raquel, Muñoz-Castro, Clara, De Castro, Vanessa, Sanchez-Mejias, Elisabeth, Navarro, Victoria, Jimenez, Sebastian, Nuñez-Diaz, Cristina, Gomez-Arboledas, Angela, Moreno-Gonzalez, Ines, Vizuete, Marisa, Davila, Jose Carlos, Vitorica, Javier, Gutierrez, Antonia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479116/
https://ncbi.nlm.nih.gov/pubmed/32901091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71767-4
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