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Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

Macroautophagy initiates by formation of isolation membranes, but the source of phospholipids for the membrane biogenesis remains elusive. Here, we show that autophagic membranes incorporate newly synthesized phosphatidylcholine, and that CTP:phosphocholine cytidylyltransferase β3 (CCTβ3), an isofor...

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Publicat a:Nat Commun
Autors principals: Ogasawara, Yuta, Cheng, Jinglei, Tatematsu, Tsuyako, Uchida, Misaki, Murase, Omi, Yoshikawa, Shogo, Ohsaki, Yuki, Fujimoto, Toyoshi
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479109/
https://ncbi.nlm.nih.gov/pubmed/32900992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18153-w
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