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Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets

Macroautophagy initiates by formation of isolation membranes, but the source of phospholipids for the membrane biogenesis remains elusive. Here, we show that autophagic membranes incorporate newly synthesized phosphatidylcholine, and that CTP:phosphocholine cytidylyltransferase β3 (CCTβ3), an isofor...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ogasawara, Yuta, Cheng, Jinglei, Tatematsu, Tsuyako, Uchida, Misaki, Murase, Omi, Yoshikawa, Shogo, Ohsaki, Yuki, Fujimoto, Toyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7479109/
https://ncbi.nlm.nih.gov/pubmed/32900992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18153-w
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