IL-6 induced upregulation of T-type Ca(2+) currents and sensitization of DRG nociceptors is attenuated by MNK inhibition

Phosphorylation of the 5′ cap-binding protein eIF4E by MAPK-interacting kinases (MNK1/2) is important for nociceptor sensitization and the development of chronic pain. IL-6-induced dorsal root ganglion (DRG) nociceptor excitability is attenuated in mice lacking eIF4E phosphorylation, in MNK1/2(−/−)...

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Detalhes bibliográficos
Publicado no:J Neurophysiol
Main Authors: Jeevakumar, Vivek, Al Sardar, Aysha Khalid, Mohamed, Farah, Smithhart, Clay Matthew, Price, Theodore, Dussor, Gregory
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474456/
https://ncbi.nlm.nih.gov/pubmed/32519575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00188.2020
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