Sarsasapogenin Suppresses RANKL-Induced Osteoclastogenesis in vitro and Prevents Lipopolysaccharide-Induced Bone Loss in vivo

INTRODUCTION: Osteoclasts are giant polynuclear cells; their main function is bone resorption. An increased number of osteoclasts and enhanced bone resorption exert significant effects on osteoclast-related bone-lytic diseases, including osteoporosis. Given the limitations of current therapies for o...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Peng, Jiaxuan, Zhao, Kangxian, Zhu, Jiling, Wang, Yanben, Sun, Peng, Yang, Qichang, Zhang, Tan, Han, Weiqi, Hu, Wenjun, Yang, Wanlei, Ruan, Jianwei, Qian, Yu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7474134/
https://ncbi.nlm.nih.gov/pubmed/32943842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S256867
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