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A regulated NMD mouse model supports NMD inhibition as a viable therapeutic option to treat genetic diseases
Nonsense-mediated mRNA decay (NMD) targets mRNAs that contain a premature termination codon (PTC) for degradation, preventing their translation. By altering the expression of PTC-containing mRNAs, NMD modulates the inheritance pattern and severity of genetic diseases. NMD also limits the efficiency...
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| 出版年: | Dis Model Mech |
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| 主要な著者: | , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Company of Biologists Ltd
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7473645/ https://ncbi.nlm.nih.gov/pubmed/32737261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.044891 |
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