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Concept of Pharmacologic Target-Mediated Drug Disposition (TMDD) in Large-Molecule and Small-Molecule Compounds

Target-mediated drug disposition (TMDD) is a term to describe a nonlinear pharmacokinetics (PK) phenomenon that is caused by high-affinity binding of a compound to its pharmacologic targets. As the interaction between drug and its pharmacologic target belongs to the process of pharmacodynamics (PD),...

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Detalhes bibliográficos
Publicado no:J Clin Pharmacol
Autor principal: An, Guohua
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472685/
https://ncbi.nlm.nih.gov/pubmed/31793004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.1545
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