A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice

Enterovirus 71 (EV71) is the major causative pathogen of human hand, foot, and mouth disease (hHFMD) and has evolved to use various cellular receptors for infection. However, the relationship between receptor preference and EV71 virulence has not been fully revealed. By using reverse genetics, we id...

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Bibliographic Details
Published in:Viruses
Main Authors: Ke, Xianliang, Zhang, Yuan, Liu, Yan, Miao, Yuanjiu, Zheng, Caishang, Luo, Dan, Sun, Jianhong, Hu, Qinxue, Xu, Yi, Wang, Hanzhong, Zheng, Zhenhua
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7472116/
https://ncbi.nlm.nih.gov/pubmed/32823486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v12080883
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