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Stabilization of human telomeric RNA G-quadruplex by the water-compatible optically pure and biologically-active metallohelices

RNA G-quadruplexes have been suggested to play key roles in fundamental biological processes and are linked to human diseases. Thus, they also represent good potential therapeutic targets. Here, we describe, using the methods of molecular biophysics, interactions of a series of biologically-active s...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Malina, Jaroslav, Scott, Peter, Brabec, Viktor
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471899/
https://ncbi.nlm.nih.gov/pubmed/32884069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-71429-5
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