COVID-19-activated SREBP2 disturbs cholesterol biosynthesis and leads to cytokine storm

Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in COVID-19 patients is unknown. Here, we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 pati...

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Veröffentlicht in:Signal Transduct Target Ther
Hauptverfasser: Lee, Wonhwa, Ahn, June Hong, Park, Hee Ho, Kim, Hong Nam, Kim, Hyelim, Yoo, Youngbum, Shin, Hyosoo, Hong, Kyung Soo, Jang, Jong Geol, Park, Chun Gwon, Choi, Eun Young, Bae, Jong-Sup, Seo, Young-Kyo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471497/
https://ncbi.nlm.nih.gov/pubmed/32883951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-020-00292-7
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