Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels

Geissoschizine methyl ether (GM) is an indole alkaloid isolated from Uncaria rhynchophyll (UR) that has been used for the treatment of epilepsy in traditional Chinese medicine. An early study in a glutamate-induced mouse seizure model demonstrated that GM was one of the active ingredients of UR. In...

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Vydáno v:Acta Pharmacol Sin
Hlavní autoři: Xie, Zhu-qing, Tian, Xiao-ting, Zheng, Yue-ming, Zhan, Li, Chen, Xue-qin, Xin, Xiao-ming, Huang, Cheng-gang, Gao, Zhao-bing
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Singapore 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471432/
https://ncbi.nlm.nih.gov/pubmed/31911638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0327-4
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