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Antiepileptic geissoschizine methyl ether is an inhibitor of multiple neuronal channels

Geissoschizine methyl ether (GM) is an indole alkaloid isolated from Uncaria rhynchophyll (UR) that has been used for the treatment of epilepsy in traditional Chinese medicine. An early study in a glutamate-induced mouse seizure model demonstrated that GM was one of the active ingredients of UR. In...

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Publicat a:Acta Pharmacol Sin
Autors principals: Xie, Zhu-qing, Tian, Xiao-ting, Zheng, Yue-ming, Zhan, Li, Chen, Xue-qin, Xin, Xiao-ming, Huang, Cheng-gang, Gao, Zhao-bing
Format: Artigo
Idioma:Inglês
Publicat: Springer Singapore 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471432/
https://ncbi.nlm.nih.gov/pubmed/31911638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0327-4
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