In vitro generation of functional murine heart organoids via FGF4 and extracellular matrix

Our understanding of the spatiotemporal regulation of cardiogenesis is hindered by the difficulties in modeling this complex organ currently by in vitro models. Here we develop a method to generate heart organoids from mouse embryonic stem cell-derived embryoid bodies. Consecutive morphological chan...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Lee, Jiyoung, Sutani, Akito, Kaneko, Rin, Takeuchi, Jun, Sasano, Tetsuo, Kohda, Takashi, Ihara, Kensuke, Takahashi, Kentaro, Yamazoe, Masahiro, Morio, Tomohiro, Furukawa, Tetsushi, Ishino, Fumitoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7471119/
https://ncbi.nlm.nih.gov/pubmed/32883967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18031-5
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