Resolving Toxic DNA repair intermediates in every E. coli replication cycle: critical roles for RecG, Uup and RadD

DNA lesions or other barriers frequently compromise replisome progress. The SF2 helicase RecG is a key enzyme in the processing of postreplication gaps or regressed forks in Escherichia coli. A deletion of the recG gene renders cells highly sensitive to a range of DNA damaging agents. Here, we demon...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Autores principales: Romero, Zachary J, Chen, Stefanie H, Armstrong, Thomas, Wood, Elizabeth A, van Oijen, Antoine, Robinson, Andrew, Cox, Michael M
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2020
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470958/
https://ncbi.nlm.nih.gov/pubmed/32644157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkaa579
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