Uncarboxylated osteocalcin ameliorates hepatic glucose and lipid metabolism in KKAy mice via activating insulin signaling pathway

Osteocalcin, expressed in osteoblasts of the bone marrow, undergoes post-translational carboxylation and deposits in mineralized bone matrix. A portion of osteocalcin remains uncarboxylated (uncarboxylated osteocalcin, GluOC) that is released into blood where it functions as a hormone to regulate in...

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Bibliographic Details
Published in:Acta Pharmacol Sin
Main Authors: Zhang, Xiao-lin, Wang, Ya-nan, Ma, Lu-yao, Liu, Zhong-sheng, Ye, Fei, Yang, Jian-hong
Format: Artigo
Language:Inglês
Published: Springer Singapore 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470804/
https://ncbi.nlm.nih.gov/pubmed/31659239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41401-019-0311-z
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