Purified IgG from aquaporin-4 neuromyelitis optica spectrum disorder patients alters blood-brain barrier permeability

BACKGROUND: Neuromyelitis optica spectrum disorders (NMOSD) is a primary astrocytopathy driven by antibodies directed against the aquaporin-4 water channel located at the end-feet of the astrocyte. Although blood-brain barrier (BBB) breakdown is considered one of the key steps for the development an...

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Veröffentlicht in:PLoS One
Hauptverfasser: Cobo-Calvo, Alvaro, Ruiz, Anne, Richard, Chloé, Blondel, Sandrine, Cavagna, Sylvie, Strazielle, Nathalie, Ghersi-Egea, Jean-François, Giraudon, Pascale, Marignier, Romain
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2020
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7470361/
https://ncbi.nlm.nih.gov/pubmed/32881954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0238301
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