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Identification of probe-quality degraders for Poly(ADP-ribose) polymerase-1 (PARP-1)
Poly(ADP-ribose) polymerase-1 (PARP-1), a critical DNA repair enzyme in the base excision repair pathway, has been pursued as an attractive cancer therapeutic target. Intervention with PARP-1 has been proved to be more sensitive to cancer cells carrying BRCA1/2 mutations. Several PARP-1 inhibitors h...
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| Publicado no: | J Enzyme Inhib Med Chem |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7470090/ https://ncbi.nlm.nih.gov/pubmed/32779949 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2020.1804382 |
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