Impact of DPYD, DPYS, and UPB1 gene variations on severe drug‐related toxicity in patients with cancer

Cancer treatment with a fluoropyrimidine (FP) is often accompanied by severe toxicity that may be dependent on the activity of catalytic enzymes encoded by the DPYD, DPYS, and UPB1 genes. Genotype‐guided dose individualization of FP therapy has been proposed in western countries, but our knowledge o...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Yokoi, Katsuyuki, Nakajima, Yoko, Matsuoka, Hiroshi, Shinkai, Yasuko, Ishihara, Takuma, Maeda, Yasuhiro, Kato, Takema, Katsuno, Hidetoshi, Masumori, Koji, Kawada, Kenji, Yoshikawa, Tetsushi, Ito, Tetsuya, Kurahashi, Hiroki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469832/
https://ncbi.nlm.nih.gov/pubmed/32619063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.14553
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