A Gli inhibitor GANT61 suppresses cell proliferation, promotes cell apoptosis and induces G1/G0 cycle retardation with a dose- and time-dependent manner through inhibiting Notch pathway in multiple myeloma

PURPOSE: This study aimed to explore the effect of GANT61 on regulating cell proliferation, cell apoptosis and cell cycle, and to investigate whether GANT61 would function in multiple myeloma (MM) via inhibiting Notch pathway. Methods: RPMI-8226 and U266 cells were treated by GANT61 (0, 2.5, 5.0, 10...

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Udgivet i:Cell Cycle
Main Authors: Zhang, Zhihua, Hao, Changlai, Zhang, Rongjuan, Pei, Xiaochuan, Li, Jundong, Wang, Lihong
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469628/
https://ncbi.nlm.nih.gov/pubmed/32677544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1792686
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