Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven inflammation

BACKGROUND: Sepsis remains a leading cause of death in critically ill patients. It is well known that mesenchymal stem cells (MSCs) are a promising therapy partly due to their paracrine-mediated immunoregulatory function. Previous study demonstrated that transforming growth factor-beta1 (TGF-β1) is...

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Veröffentlicht in:Stem Cell Res Ther
Hauptverfasser: Liu, Feng, Xie, Jianfeng, Zhang, Xiwen, Wu, Zongsheng, Zhang, Shi, Xue, Ming, Chen, Jianxiao, Yang, Yi, Qiu, Haibo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7469348/
https://ncbi.nlm.nih.gov/pubmed/32883356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-020-01894-2
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