Ex vivo use of cell-permeable succinate prodrug attenuates mitochondrial dysfunction in blood cells obtained from carbon monoxide-poisoned individuals

The purpose of this study was to evaluate a new pharmacological strategy using a first-generation succinate prodrug, NV118, in peripheral blood mononuclear cells (PBMCs) obtained from subjects with carbon monoxide (CO) poisoning and healthy controls. We obtained human blood cells from subjects with...

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Détails bibliographiques
Publié dans:Am J Physiol Cell Physiol
Auteurs principaux: Owiredu, Shawn, Ranganathan, Abhay, Eckmann, David M., Shofer, Frances S., Hardy, Kevin, Lambert, David S., Kelly, Matthew, Jang, David H.
Format: Artigo
Langue:Inglês
Publié: American Physiological Society 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468892/
https://ncbi.nlm.nih.gov/pubmed/32374677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00539.2019
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