Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids. Using a high-through...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nat Chem Biol
Autores principales: Mock, Elliot D., Mustafa, Mohammed, Gunduz-Cinar, Ozge, Cinar, Resat, Petrie, Gavin N., Kantae, Vasudev, Di, Xinyu, Ogasawara, Daisuke, Varga, Zoltan V., Paloczi, Janos, Miliano, Cristina, Donvito, Giulia, van Esbroeck, Annelot C. M., van der Gracht, Anouk M. F., Kotsogianni, Ioli, Park, Joshua K., Martella, Andrea, van der Wel, Tom, Soethoudt, Marjolein, Jiang, Ming, Wendel, Tiemen J., Janssen, Antonius P. A., Bakker, Alexander T., Donovan, Colleen M., Castillo, Laura I., Florea, Bogdan I., Wat, Jesse, van den Hurk, Helma, Wittwer, Matthias, Grether, Uwe, Holmes, Andrew, van Boeckel, Constant A. A., Hankemeier, Thomas, Cravatt, Benjamin F., Buczynski, Matthew W., Hill, Matthew N., Pacher, Pal, Lichtman, Aron H., van der Stelt, Mario
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
Materias:
Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7468568/
https://ncbi.nlm.nih.gov/pubmed/32393901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0528-7
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares