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The dynamic nature of the human origin recognition complex revealed through five cryoEM structures

Genome replication is initiated from specific origin sites established by dynamic events. The Origin Recognition Complex (ORC) is necessary for orchestrating the initiation process by binding to origin DNA, recruiting CDC6, and assembling the MCM replicative helicase on DNA. Here we report five cryo...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Jaremko, Matt J, On, Kin Fan, Thomas, Dennis R, Stillman, Bruce, Joshua-Tor, Leemor
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467728/
https://ncbi.nlm.nih.gov/pubmed/32808929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.58622
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