Combined Chemisorption and Complexation Generate siRNA Nanocarriers with Biophysics Optimized for Efficient Gene Knockdown and Air–Blood Barrier Crossing

[Image: see text] Current nucleic acid (NA) nanotherapeutic approaches face challenges because of shortcomings such as limited control on loading efficiency, complex formulation procedure involving purification steps, low load of NA cargo per nanoparticle, endosomal trapping, and hampered release in...

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Detalhes bibliográficos
Publicado no:ACS Appl Mater Interfaces
Main Authors: Taschauer, Alexander, Polzer, Wolfram, Pöschl, Stefan, Metz, Slavica, Tepe, Nathalie, Decker, Simon, Cyran, Norbert, Scholda, Julia, Maier, Julia, Bloß, Hermann, Anton, Martina, Hofmann, Thilo, Ogris, Manfred, Sami, Haider
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467563/
https://ncbi.nlm.nih.gov/pubmed/32515194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsami.0c06608
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