Implementation of a Reference-Scaled Average Bioequivalence Approach for Highly Variable Acetylsalicylic Acid in Fixed-Dose Combination with Clopidogrel Versus Enteric Aspirin in Chinese Subjects Under Fasting Conditions: A Phase 1, Open-Label, Randomized, Crossover Study

INTRODUCTION: Dual antiplatelet therapy, aspirin and a P2Y(12) inhibitor, is recommended to prevent thrombotic complications of acute coronary syndrome. Clopidogrel plus acetylsalicylic acid combination is the most commonly used dual antiplatelet therapy recommended by international guidelines and i...

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Vydáno v:Adv Ther
Hlavní autoři: Wang, Lu, Di, Yujing, Guo, Tingting, Ming, Jeffrey E., Kong, Fangyuan, Yin, Huiqiu, Zhang, Linlin, Xie, Fang, Yang, Na, Ping, Chuan, Li, Yi, Hou, Jie
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Healthcare 2020
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7467447/
https://ncbi.nlm.nih.gov/pubmed/32418143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12325-020-01369-z
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