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Safety range of free valproic acid serum concentration in adult patients
BACKGROUND: Therapeutic drug monitoring (TDM) is recommended during valproic acid (VPA) use, and total serum concentration has been widely adopted. However, the free form of VPA is responsible for its pharmacologic and toxic effects, and the total and free concentrations are highly discordant becaus...
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| Publicado no: | PLoS One |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7467252/ https://ncbi.nlm.nih.gov/pubmed/32877431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0238201 |
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