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SIR2 Expression Noise Can Generate Heterogeneity in Viability but Does Not Affect Cell-to-Cell Epigenetic Silencing of Subtelomeric URA3 in Yeast

Chromatin structure clearly modulates gene expression noise, but the reverse influence has never been investigated, namely how the cell-to-cell expression heterogeneity of chromatin modifiers may generate variable rates of epigenetic modification. Sir2 is a well-characterized histone deacetylase of...

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Détails bibliographiques
Publié dans:G3 (Bethesda)
Auteurs principaux: Liu, Jian, Mosser, Laureline, Botanch, Catherine, François, Jean-Marie, Capp, Jean-Pascal
Format: Artigo
Langue:Inglês
Publié: Genetics Society of America 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7466964/
https://ncbi.nlm.nih.gov/pubmed/32727919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.120.401589
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