TCGA mRNA Expression Analysis of the Heme Biosynthesis Pathway in Diffusely Infiltrating Gliomas: A Comparison of Typically 5-ALA Fluorescent and Non-Fluorescent Gliomas

5-Aminolevulinic acid (5-ALA) is a fluorescent dye that after metabolization to Protoporphyrin IX (PpIX) by the heme biosynthesis pathway typically leads to visible fluorescence in WHO grade IV but not grade II gliomas. The exact mechanism for high PpIX levels in WHO grade IV gliomas and low PpIX le...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Mischkulnig, Mario, Kiesel, Barbara, Lötsch, Daniela, Roetzer, Thomas, Borkovec, Martin, Wadiura, Lisa I., Mercea, Petra A., Jaklin, Florian J., Hervey-Jumper, Shawn, Roessler, Karl, Berger, Mitchel S., Widhalm, Georg, Erhart, Friedrich
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7466145/
https://ncbi.nlm.nih.gov/pubmed/32722247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082043
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