Actively Targeted Nanodelivery of Echinomycin Induces Autophagy-Mediated Death in Chemoresistant Pancreatic Cancer In Vivo

Pancreatic cancer remains a recalcitrant neoplasm associated with chemoresistance and high fatality. Because it is frequently resistant to apoptosis, exploiting autophagic cell death could offer a new treatment approach. We repurpose echinomycin, an antibiotic encapsulated within a syndecan-1 active...

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Библиографические подробности
Опубликовано в: :Cancers (Basel)
Главные авторы: Thomas, Alexandra, Samykutty, Abhilash, Gomez-Gutierrez, Jorge G., Yin, Wenyuan, Egger, Michael E., McNally, Molly, Chuong, Phillip, MacCuaig, William M., Albeituni, Sabrin, Zeiderman, Matthew, Li, Min, Edil, Barish H., Grizzle, William E., McMasters, Kelly M., McNally, Lacey R.
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464900/
https://ncbi.nlm.nih.gov/pubmed/32823919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12082279
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