S-Adenosylmethionine Treatment of Colorectal Cancer Cell Lines Alters DNA Methylation, DNA Repair and Tumor Progression-Related Gene Expression

Global DNA hypomethylation is a characteristic feature of colorectal carcinoma (CRC). The tumor inhibitory effect of S-adenosylmethionine (SAM) methyl donor has been described in certain cancers including CRC. However, the molecular impact of SAM treatment on CRC cell lines with distinct genetic fea...

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Veröffentlicht in:Cells
Hauptverfasser: Zsigrai, Sára, Kalmár, Alexandra, Nagy, Zsófia B., Barták, Barbara K., Valcz, Gábor, Szigeti, Krisztina A., Galamb, Orsolya, Dankó, Titanilla, Sebestyén, Anna, Barna, Gábor, Szabó, Vanessza, Pipek, Orsolya, Medgyes-Horváth, Anna, Csabai, István, Tulassay, Zsolt, Igaz, Péter, Takács, István, Molnár, Béla
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464653/
https://ncbi.nlm.nih.gov/pubmed/32784836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells9081864
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