Pirfenidone inhibits cryoablation induced local macrophage infiltration along with its associated TGFb1 expression and serum cytokine level in a mouse model

PURPOSE: To investigate the effects of pirfenidone (PFD) on post-cryoablation inflammation in a mouse model. MATERIALS AND METHODS: In this IACUC-approved study, eighty Balb/c mice were randomly divided into four groups (20/group): sham+vehicle, sham+PFD, cryoablation+vehicle, and cryoablation+PFD....

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Publicat a:Cryobiology
Autors principals: Gu, Yangkui, Srimathveeravalli, Govindarajan, Cai, Liqun, Ueshima, Eisuke, Maybody, Majid, Yarmohammadi, Hooman, Zhu, Yuan-Shan, Durack, Jeremy C, Solomon, Stephen B, Coleman, Jonathan A, Erinjeri, Joseph P
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7464590/
https://ncbi.nlm.nih.gov/pubmed/29621494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cryobiol.2018.03.012
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