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Population‐level multiplexing: A promising strategy to manage the evolution of resistance against gene drives targeting a neutral locus
CRISPR‐based gene drives bias inheritance in their favour by inducing double‐stranded breaks (DSBs) at wild‐type homologous loci and using the drive transgene as a repair template—converting drive heterozygotes into homozygotes. Recent studies have shown that alternate end‐joining repair mechanisms...
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| Udgivet i: | Evol Appl |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7463328/ https://ncbi.nlm.nih.gov/pubmed/32908596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/eva.12945 |
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