Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing To Define Immune Cell Chimerism in the Rejecting Kidney Transplant

BACKGROUND: In solid organ transplantation, donor-derived immune cells are assumed to decline with time after surgery. Whether donor leukocytes persist within kidney transplants or play any role in rejection is unknown, however, in part because of limited techniques for distinguishing recipient from...

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Bibliografiske detaljer
Udgivet i:J Am Soc Nephrol
Main Authors: Malone, Andrew F., Wu, Haojia, Fronick, Catrina, Fulton, Robert, Gaut, Joseph P., Humphreys, Benjamin D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Nephrology 2020
Fag:
Basic Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461682/
https://ncbi.nlm.nih.gov/pubmed/32669324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020030326
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