Harnessing Expressed Single Nucleotide Variation and Single Cell RNA Sequencing To Define Immune Cell Chimerism in the Rejecting Kidney Transplant

BACKGROUND: In solid organ transplantation, donor-derived immune cells are assumed to decline with time after surgery. Whether donor leukocytes persist within kidney transplants or play any role in rejection is unknown, however, in part because of limited techniques for distinguishing recipient from...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Malone, Andrew F., Wu, Haojia, Fronick, Catrina, Fulton, Robert, Gaut, Joseph P., Humphreys, Benjamin D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2020
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7461682/
https://ncbi.nlm.nih.gov/pubmed/32669324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2020030326
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