A small targeting domain in Ty1 integrase is sufficient to direct retrotransposon integration upstream of tRNA genes

Integration of transposable elements into the genome is mutagenic. Mechanisms targeting integrations into relatively safe locations, hence minimizing deleterious consequences for cell fitness, have emerged during evolution. In budding yeast, integration of the Ty1 LTR retrotransposon upstream of RNA...

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Bibliographic Details
Published in:EMBO J
Main Authors: Asif‐Laidin, Amna, Conesa, Christine, Bonnet, Amandine, Grison, Camille, Adhya, Indranil, Menouni, Rachid, Fayol, Hélène, Palmic, Noé, Acker, Joël, Lesage, Pascale
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7459421/
https://ncbi.nlm.nih.gov/pubmed/32677087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2019104337
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