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VRK-1 extends life span by activation of AMPK via phosphorylation

Vaccinia virus–related kinase (VRK) is an evolutionarily conserved nuclear protein kinase. VRK-1, the single Caenorhabditis elegans VRK ortholog, functions in cell division and germline proliferation. However, the role of VRK-1 in postmitotic cells and adult life span remains unknown. Here, we show...

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Bibliografiske detaljer
Udgivet i:Sci Adv
Main Authors: Park, Sangsoon, Artan, Murat, Han, Seung Hyun, Park, Hae-Eun H., Jung, Yoonji, Hwang, Ara B., Shin, Won Sik, Kim, Kyong-Tai, Lee, Seung-Jae V.
Format: Artigo
Sprog:Inglês
Udgivet: American Association for the Advancement of Science 2020
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458447/
https://ncbi.nlm.nih.gov/pubmed/32937443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaw7824
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