Human papillomavirus type 38 alters wild-type p53 activity to promote cell proliferation via the downregulation of integrin alpha 1 expression

Tumor suppressors can exert pro-proliferation functions in specific contexts. In the beta human papillomavirus type 38 (HPV38) experimental model, the viral proteins E6 and E7 promote accumulation of a wild-type (WT) p53 form in human keratinocytes (HKs), promoting cellular proliferation. Inactivati...

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Udgivet i:PLoS Pathog
Main Authors: Romero-Medina, Maria Carmen, Venuti, Assunta, Melita, Giusi, Robitaille, Alexis, Ceraolo, Maria Grazia, Pacini, Laura, Sirand, Cecilia, Viarisio, Daniele, Taverniti, Valerio, Gupta, Purnima, Scalise, Mariafrancesca, Indiveri, Cesare, Accardi, Rosita, Tommasino, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2020
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7458291/
https://ncbi.nlm.nih.gov/pubmed/32813746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008792
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