Intestinal stenosis in Crohn’s disease shows a generalized upregulation of genes involved in collagen metabolism and recognition that could serve as novel anti-fibrotic drug targets

BACKGROUND AND AIMS: Crohn’s disease (CD) can be complicated by intestinal fibrosis. Pharmacological therapies against intestinal fibrosis are not available. The aim of this study was to determine whether pathways involved in collagen metabolism are upregulated in intestinal fibrosis, and to discuss...

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Опубликовано в: :Therap Adv Gastroenterol
Главные авторы: van Haaften, Wouter Tobias, Blokzijl, Tjasso, Hofker, Hendrik Sijbrand, Olinga, Peter, Dijkstra, Gerard, Bank, Ruud A., Boersema, Miriam
Формат: Artigo
Язык:Inglês
Опубликовано: SAGE Publications 2020
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7457685/
https://ncbi.nlm.nih.gov/pubmed/32922514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1756284820952578
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